As a developer, I install and uninstall all sort of programs on my system so I am not surprised when some weird and random error message popped up. I ran into the following error dialog today when I was writing some .NET integration code with EMC AppXtender.
This exception was thrown when I was trying to create the AppXtender DBConnection object. So I fired up the AppXtender Document Manager to verify my installation and it ran successfully.
Going back to my Visual Studio project, I verified the Interop.AEXDBLib reference and that seems right. A quick search on MSDN on error code 80040154 showed a list of COM errors on 32-bit OS, and I am seeing this error on my 64-bit OS.
The fix is to change the Platform target of my .NET solution to x86.
Hope this helps.